Flexeril, Amrix cyclobenzaprine dosing, indications, interactions, adverse effects, and more

Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Cyclobenzaprine is a centrally acting skeletal flexeril controlled muscle relaxant structurally related to tricyclic antidepr[7]essants. Cyclobenzaprine relieves skeletal muscle spasms of local origin without interfering with muscle function. In preclinical research, cyclobenzaprine reduced skeletal muscle hyperactivity.

It may not be safe to breast-feed while using this medicine. Flexeril may also be used for purposes not listed in this medication guide.

Call your doctor or local poison control center if you think you’ve taken too much of this drug. Call 911 or go to the nearest emergency room immediately if your symptoms are severe. To help avoid interactions, your doctor should manage all of your medications carefully.

Cyclobenzaprine (Oral Route)

Serotonin syndrome occurs when you take medications that cause an excess of serotonin in your system. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Although not all of these side effects may occur, if they do occur they may need medical attention. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

• The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies.
• This is more likely to happen in the few hours after you take it.
• Do not take more or less of it or take it more often than prescribed by your doctor.
• There is also evidence that cyclical antidepressants may decrease the seizure threshold by interfering with chloride conductance on the GABA receptor.
• It is usually used in conjunction with physical therapy.
• To help avoid interactions, your doctor should manage all of your medications carefully.

Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems. In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration.

Postmarketing Reports

The overall effectiveness of FLEXERIL was similar to that observed in the double-blind controlled studies; the overall incidence of adverse effects was less (see ADVERSE REACTIONS). These patients are generally more susceptible to drugs with potentially sedating effects, including cyclobenzaprine. FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with a 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended. The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies. Consider a longer-term detox and treatment facility if a professional has told you that your Flexeril and alcohol abuse is severe or if you’ve relapsed several times in the past.

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This means you may need to take it with other medications. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe. Tell your care team if your symptoms do not start to get better or if they get worse. Talk to your care team about the use of this medication in children.

Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. CVS.com® is not available to customers or patients who are located outside of the United States or U.S. territories. We work with your doctor or local pharmacist to take care of transfers, refill requests, and more. All FDA-approved generics must have the same strength, dosage form, safety and effectiveness as their brand-name counterparts. All generic medications sold through Blink Health are FDA-approved.

Cyclobenzaprine (Flexeril) is structurally similar to TCAs and, as such, demonstrates significant anticholinergic side effects. It differs from the TCA amitriptyline by only one double bond. It is generally used for musculoskeletal conditions, including fibromyalgia and low back pain. Cyclobenzaprine is best used in short-term treatment but may be used intermittently or long-term for chronic pain. Another potential side effect of Flexeril is overdose if an individual takes too much of the drug.